Sodium chloride is used as a source of electrolytes (minerals in body fluids) and water to prevent dehydration (when loss of water exceeds water intake) and replenish the loss of sodium from body fluids in conditions like metabolic alkalosis (acid-base imbalance in body fluids that can cause serious complications) or diarrhoea. Nasal Solution is a non-medicated, preservative free saline irrigation sachet for nasal and sinus washing. When mixed with lukewarm water, each 4.0 g sachet will produce 200 ml of saline wash for use. This solution is an alkaline buffered hypertonic (2%) saline with xylitol. Saline Nasal Irrigation (SNI) is known to be an adjunctive therapy for upper respiratory conditions which bathes the nasal cavity with saline solution. It is a simple, inexpensive procedure that has been used to treat upper respiratory conditions especially of the nasal cavity and the sinuses. SNI really is as simple as running a gentle saline solution through the nasal passages and sinuses. The procedure involves flushing the nasal cavity with saline solution which improves mucociliary clearance by moisturizing the nasal cavity and removing encrusted material. For the purpose of nasal irrigation, a high number of irrigation systems and methods are offered.

Indications:
● Sinusitis
● Cold
● Flu
● Allergies
● Allergic rhinitis
● Runny Nose
● Removes inhaled irritants (dust, pollen)
● Nasal Stuffiness

Mechanism of Action:
Saline Nasal Irrigation (SNI) is primarily a mechanical intervention leading to direct cleaning of the nasal mucosa, independent of the composition of the solution used for nasal washing. The mucus lining the nasal cavity may be softened and dislodged. Moreover, inflammatory mediators-such as prostaglandins and leukotrienes-and antigens responsible for allergic reactions can be removed favoring resolution of URTIs and AR. Impact of the salt concentration on mucociliary clearance through a modification of ciliary beating frequency is not defined because data collected in vitro and in vivo have been contradictory, it has been demonstrated that the composition and activity of nasal secretions are related to the tonicity of the solution. Administration of low-salt and isotonic solutions has been associated with an immediate, significant reduction in the microbial antigens and a related decline of microbial burden. In contrast, hypertonic solutions were found to be only marginally capable of influencing microbial antigen concentrations. Benzalkonium Chloride acts as a preservative.

Contraindications:
● Known hypersensitivity to the active ingredient or any of the Excipients
● Patients with trans-sphenoidal hypophysectomy or surgery exposing the dura mater

Warning & Precautions:
● Patients are advised not to take decongestants for more than seven consecutive days and should be used only with caution in patients showing a strong reaction to sympathomimetic agents as evidenced by signs of insomnia, dizziness etc.
● Caution is recommended in patients with hypertension, cardiovascular disease, hyperthyroidism, narrow angle glaucoma or diabetes mellitus.

Interactions:
The formulation may interact with the following medications:
● Potassium supplements;
● Diuretic or "water pill";
● Steroid such as prednisone, fluticasone, mometasone, dexamethasone, and others;
● Blood pressure medication; or
● Medication that contains sodium, such as omeprazole and sodium bicarbonate.

Pregnancy & Lactation:
No foetal toxicity or fertility studies have been reported. If you are pregnant or taking any other medicines or are under a doctor's care, consult him before using nasal solution.
No evidence of any adverse effect on the breast-fed infant. However, it is not known if xylometazoline is excreted in breast milk, therefore caution should be exercised and should be used only on the advice of a doctor whilst breastfeeding.

Storage:
Store in a cool and dry place. Protect from direct sunlight.